Pennsylvania stands to gain “tens of millions” more in taxes once the state's new guidelines for collecting online sales taxes take full effect, while businesses try to figure out how to adapt to new rules in other states, as well.

Hanover Logistics has purchased the former 325,000-square foot GlaxoSmithKline Distribution Center in Penn Township Industrial Park.

Republican state lawmakers joined doctors on the steps of the Pennsylvania Capitol's main rotunda for a rally Wednesday to denounce a proposed rule change by the state Supreme Court they say would jeopardize Pennsylvania health care.

LifeChanges Boutique Inc., a provider of products and services for breast cancer patients in Hanover, has been purchased by a small Maryland-based chain

UPMC Pinnacle is closing its Bariatric and Metabolic Institute in Lancaster and plans to transition the institute's weight-loss surgeries and other services to its Harrisburg weight-loss center.

Gov. Tom Wolf has renewed his call for a $15 minimum wage in Pennsylvania and set a schedule to get there by 2025.

A Dauphin County office building occupied by an education and human services provider has been sold for $3.4 million to an investment company.

Nikki Haley, the former U.S. ambassador to the United Nations and governor of South Carolina, will serve as the keynote speaker at the Pennsylvania Chamber of Business and Industry's annual chamber dinner this fall.

Doug Gellatly loves the wine business, but he's even more bullish about pet resorts.

Giant Food Stores' new e-commerce hub, Giant Direct Powered by Peapod, is expected to open on Feb. 12, offering grocery delivery and pickup from its Lancaster city storefront.

Central Pennsylvanian farmers could begin growing one of the top cash-producing crops in the country by 2020 if a pharmaceutical company picks the state to grow a plant used in malaria medication.

Four months ago, Robert and Amanda Hasemeier were getting a home makeover from Ed Lank Kitchens & Baths.

An historic York County wedding venue has been listed for sale.

Citing a lack of space and the desire for a more modern facility, one of Central Pennsylvania's largest private companies is moving its headquarters.

York County has unleashed a new brand designed to attract visitors: “Have It Made Here.”